Arteries can weaken over time due to a mix of lifestyle, health, and age-related factors. High blood pressure puts constant strain on artery walls, making them stiff and prone to damage. High cholesterol and diets rich in processed fats can lead to plaque buildup, narrowing and weakening blood flow. Smoking introduces toxins that erode the lining of arteries, while diabetes raises blood sugar levels that injure blood vessels over time. Obesity, lack of exercise, and chronic stress also play a role, as they worsen inflammation and strain on the cardiovascular system. Genetics and aging further increase vulnerability.